Scientists Reverse DNA Aged in Mice, what of men?


Scientists have successfully come up with a way of protecting the DNA damage of aging mice. They want to test the same procedure with human beings.

Dr. David Sinclair of Harvard Medical school together with his colleagues have brought their findings in the newest issue of Science. Their focus was on the intriguing compound that had NAD+, an anti-aging property. NAD+ is the short form of nicotinamide adenine dinucleotide. The researchers found that young mice have more of this property than older mice. They later noticed that immediately they boosted NAD+ in aged mice, they started looking younger biologically and physically.

In the latest findings, the scientists reveal fresh details about how NAD+ works when keeping cells youthful. Sinclair drops NAD+ in water consumed by several mice, and within a few hours, the levels of NAD+ starts rising. The researchers start observing an improvement in the DNA repair and an age reversal in the muscles. You cannot differentiate between tissues of a two-year-old mouse and a four months old mouse.

The reason as to why scientists think NAD+ brings forth these effects is because this compound links to DNA repairs in the body. Every time a cell undergoes division, the DNA replicates. This process is not always perfect, and sometimes errors occur, causing the DNA to damage. Exposure to various environmental pollutants, chemicals and medical radiations from X-rays damages DNA. In most cases, these insults can undergo repair for as long as there exist enough PARPI, a DNA repair compound.

The NAD+ and the repair compound have a special link. The levels of NAD+ are high, PARPI becomes activated and starts declining. This decrease leads to accumulation of DNA damage.

Scientists have made an investment in the behavior of PARPI and NAD+ when targeting cancer cells. There is a cluster of cancer drugs named PARPI inhibitors, which work best for treating breast cancer, interfere with the ability of PARP to repair in the tumour’s DNA, which then leads to the demise of the cells. However, not all individuals that take these drugs respond well. Manipulating the NAD+ levels might be an alternative way of enhancing response.

The definitive test will be to find out if this quick DNA reversal in aged tissues in human beings is possible. The Metro biotech company in Boston is taking the leap in developing then testing an NAD+ version in people. Sinclair has come up with a capsule similar to NAD+ called the NMN (nicotinamide mononucleotide), a natural compound found in foods like cucumber, broccoli, edamame, and avocado. The test will be done on 25 people to authenticate its safety.

If the results become positive, Sinclair says that using NAD+ for protecting age-related DNA damage will have broad applications like shielding people living with cancer from radiation effects and protecting individuals who have high exposure to radiations in working environments.

The impression is protecting the body from exposure to radiations that come from nature or doctors. He says that you can take an NMN before heading for CT scan or an X-ray. NASA will collaborate with Sinclair so that they can insulate astronauts from cosmic radiations while in space.

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Tim is an independent journalist at the Pro Tribune.